Influence of antimicrobial chemotherapy on the serum concentrations of acute phase reactants in patients with active pulmonary tuberculosis

Aktif akciğer tüberkülozlu hastalarda antitüberküloz tedavinin serum akut faz reaktanlarının konsantrasyonu üzerine etkisi

Zeki YILDIRIM, Nuray BÜYÜKBERBER, Süleyman HACIEVLİYAGİL, Münire GÖKIRMAK, Aynur ŞAHİN

Abstract

Several acute phase reactant levels have been proposed as possible markers to monitor disease activity and res¬ponse to the treatment in patients with tuberculosis. In order to evaluate the effect of anti-tuberculous che¬motherapy on acute phase reactants, we measured the serum levels such of acute phase reactants as transfer¬rin, albumin, complement C3 and C4 and erytrocyte sedimentation rate (ESR) in 30 patients with active pul¬monary tuberculosis before and after anti-tuberculous chemotherapy. Although all acute phase reactant levels were within normal limits, before and after the treatment their levels changed during treatment. While there we¬re an increase in the concentrations of transferrin (190,6± 55,9 versus 222,8 ± 76,3 mg/dl) (p

Özet

Tilberkillozlu hastalarda akuffaz reaktanlarinin, tedaviye cevabi ve hasiahgin aktivitesini belirlemede muhte- mel marker olabilecegi one silrulmektedir. Aktif akciger tiiberkulozu olan 30 hastada akutfaz reaktanlan uze¬ rine tuberkiiloz tedavisinin etkisini degerlendirmek if in, tedaviden Once ve tedavinin 6. aymda serum trans- ferrin, albumin ve kompleman C3 ve C4 gibi akutfaz reaktanlarinin seviyelerini ve eritrosit sedimantasyon, hi- zini (ESH) b'lgtuk. Turn akutfaz reaktanlarinin serum seviyeleri normal sinirlar icinde olasina ragmen, teda- vi sirasmda duzeylerinde degisiklikler meydana geldi. Transferrin (190,6 ± 55,9 dan 222,8 ± 76,3 mg/dL'ye) (p