Coexistence of neurofibromatosis with juvenil chronic myeloid leukemia and acute lymphoblastic leukemia: Two cases report

Murat SÖKER, Özgür ÇOĞULU, Celal DEVECİOĞLU, Fuat GÜRKAN, Kenan HASPOLAT

Abstract

Neurofibromatosis (NF) is a common, autosomal dominant neurocutaneos displasia. The disorder may be pre¬sented with distincitive features like cafe au lait at birth. The disorder may be classified in two groups, NF1 or NF2. Malignant neoplasms may cause significant problems in patients with NF. Tumors ofCNS including optic glioma, meningioma, neurofibromatosis, astrocytomas, and neurillomas account for significant morbidity and mortality. The incidence ofpheochromocytoma, rhabdomyosarcoma and Wilm's tumor is higher than in the ge¬neral population. But hematologic malignancies are less frequent in NF. Here two cases, a juvenil chronic mye¬loid leukemia with NF and acute lymphoblastic laukemia with NF are presented. Children with NF should be investigated to rule out any malignancies

Özet

Norofibromatozis (NF) norokutan displaziler iginde sik rastlanan kahtsal hastahklardan biridir. gocuklarda dogumda veya dogumdan sonraki bir donemde deride multiplsiltlu kahverengi lekelergorunilmij. hastahgi du-sundiiriir. NF1 ve NF2 olarak iki gruba aynlan norofibromatozisli hastalarda klinik tabloya nadiren multipl tumor olusumunu eklenebilir. Noral tumor, noroblastoma, Wilm 's tiimoru, melanoma, hepatoma, rabdomyo-sarkoma, endokrin tilmorler gibi maligniteler ve az sayida hematolojik malignitelerle NF birlikteligi vurgulan-mistir. Bu makalede NF ile juvenil kronikmyeloid losemi ve akut lenfoblastik losemi birlikteligi iki olgu esligin-de sunulmus ve NF tanisi alan hastalann maliynite yonunden izlenmesi gerektigine dikkat cekilmistir.