Blood viscosity and its relationship with plasma fibrinogen and cholesterol levels in young obese patients

Genç obezlerde kan viskozitesi ve viskozitenin plazma fibrinojen ve kolesterol düzeyi ile ilişkisi

Arif YÖNEM, Bekir ÇAKIR, Çağlayan ÖZDEMİR, Mahmut YAZICI, Ömer AZAL, Mustafa KUTLU, Mustafa GÜNAY

Abstract

In the present study we investigated blood viscosity changes and its relationship with plasma fibrinogen and cholesterol, two of well-established cardiovascular risk factors in obese patients. Our study group consisted of 38 young obese patients with mean age 22.24±3-94 years. Thirty healthy subjects were investigated as control gro¬ up. In both study and control groups body mass index (BMI), total cholesterol and plasma fibrinogen levels, whole blood and plasma viscosity were inedsured. We have shown that in young obese patients both whole blo¬ od and plasma viscosity were significantly increased when compared with in healthy subjects and the increase in viscosity was well correlated with BMI and plasma fibrinogen level. As a result, we may suggest that haemor- heological disturbances may partly explain the increased cardiovascular morbidity and mortality in obese pa¬ tients.

Özet

Bu gah§mada obezite disinda patolojisi olmayan geng eriskinlerde, kan viskozitesinde meydana gelen degisik-likleri ve bunlann kardiyovaskuler risk faktorlerinden olan plazma fibrinojen ve kolesterol diizeyiyle iliskisini arastirdik. fahsmaya ortalama 22.24±3-94 yaslannda 38 obez hasta dahil edildi. Kontrol grubu olarak, has-talarla aym yas ve cins grubunda 30 saghkh olgu incelendi. Olgulann beden kitle indeksi, total kolesterol ve ■ plazma fibrinojen dilzeyleri belirlendikten sonra tarn kan ve plazma viskoziteleri koni-plak modelindeki bir vis-kozimetre ile iki ayrt hizda olculdii. Qahsmamizda obezlerde hem tarn kan, hem deplazma viskozitesinin sag¬hkh kisilere gore anlamh derecede (p