The evaluation of thyroid functions among asphyxiated newborns

Perinatal asfiktik yenidoğanlarda 1. ve 5. gün tiroid fonksiyonlarının değerlendirilmesi

Abstract

Our study was performed among 40 asphyxiated and 26 healthy term AGA (appropiate for gestational age) newboms who were born at Zeynep Kamil Maternity and Children's Hospital, in order to determine thyroid functions in hypoxic-ischemic infants. We obtained cord blood samples and venous blood samples on the fifth day of the life from all the newboms. The results observed in the comparison ofT3, T4, TSH, FT3 andFT4 valu¬es of these blood samples are as follows; while T4, FT4 and FT3 values in cord blood was significantly high at asphyxiated group when compared with control group. Blood samples which were obtained on the fifth day from the same newboms suggested markedly low T4 values among the asphyxiated infants while T3 and FT3 values were significantly low on the fifth day at asphyxiated group, FT4 and TSH values were similar among both groups. Low T4, FT4 and FT3 levels and high TSH levels in cord blood samples of asphyxiated group sug¬gest that hypothalamus and pituitary gland functions are not affected. But thyroid gland which needs oxygen and energy for hormon synthesis is affected from hypoxia and so its synthesis function is markedly decreased during the first five day period.

Özet

Hipoksik iskemik yenidoganlarda tiroid fonksiyonlanni incelemek amaciyla planlanan bu cahsma hastane-mizde dogan 40 perinatal asfiksili ve 26 saghkh term normal kllolu (AGA) yenidogan iXzerinde yapilmxstir. Turn yenidoganlarda ahnan kordon kam ve 5. gun venoz kan T3, T4, TSH, FT3, FT4 degerleri kar§ila§tmlmi§ ve §u sonuclar elde edilmi§tir; % ■ gun kordondan ahnan kanlarda, perinatal asfiktik grubun TT4, FT4 ve FT3 seviyeleri ileri derecede anlamh du§uk bulunurken, TT3 seviyelerinde her iki grup arasinda anlamh birfark bulunamadi. Kordon kanindaki TSH degerleri, perinatal asfiktik grupta kontrol grubuna gore ileri derecede anlamh yilksek buluhdu. Ayni bebeklerden 5. gun ahnan kanlarda TT4 dilzeyleriyine asfiktik grupta anlam-h olarak du§uk bulundu. TT3 ve FT3 degerleri ise 5. gilnde asfiktik grupta ileri derecede anlamh dusuk bulun-du. 5- gilnde FT4 ve TSH diXzeyleri ise her iki grupta da benzer bulundu. Birinci gun asfiktik grupta dusu'k bulunan TT4, FT4 ve TT3 diizeylerine karsilik TSH'in yiiksek bulunmasi vakalanmizda hipotalamus ve hipo-fizfonksiyonlarimn etkilenmedigini gostermektedir. Hormon sentezi igin oksijen ve enerjiye ihtiyaci olan tiro¬id bezi ise hipoksiden etkilenmekte ve ilk bes gilnliik evrede sentez fonksiyonlan onemli derecede azalmakta-dir.