Journals / Türk Hematoloji Onkoloji Dergisi / 1998 / Cilt: 8 - Sayı: 2
The effect of medroxyprogesterone acetate on nausea-vomiting, body weight and performance status in hormone sensitive and non-hormone sensitive cancers
- Pages
- 93–97
- DOI
- —
Abstract
The Effect of Medroxyprogesterone Acetate on Nausea-Vomiting, Body Weight and Performance Status in Hormone Sensitive and Non-Hormone Sensitive Cancers Ten patients with breast cancer (hormone sensitive) and 15patients with gastric cancer (non-hormone sensitive) who had taken their first cycle chemotherapy without medroxyprogesterone acetate (MPA), were given the second cycle chemotherapy with high dose MPA (1 g/day) for 3 or 4 weeks depending on the chosen chemotherapy regimen. An increase of body weight was observed in 10 gastric cancer patients out of 15, and 6 of İO breast cancer patients. Chemotherapy associated nausea and vomiting were decreased in 10 gastric cancer and 7 breast cancer patients. Ten gastric cancer and 7 breast cancer patients had improved performance status. No difference was observed between breast and stomach can-cer in respect of positive effects of MPA.
Özet
Birinci kür tedavileri sadece kemoterapi olarak verilen 10 meme kanserli (hormon sensitif) ve 15 mide kanserli (non-hormon sensitif) hastaya ikinci kür kemoterapi ile birlikte yüksek doz medroksiproges-teron asetat (MPA) (l g/gün), uygulanan kemoterapi protokolüne göre 3 veya 4 hafta süreyle verildi. Mide kanserli 15 hastanın 10'unda, meme kanserli 10 hastanın 6'sında vücut ağırlığında artma gözlendi. Mide kanserli 15 hastanın 10'unda, meme kanserli 10 hastanın 7'sinde kemoterapiye bağlı bulantı-kusma azaldı. Mide kanserli 15 hastanın 10'unda, meme kanserli 10 hastanın T sinde perfor-mans durumlarında iyileşme gözlendi. MPA'ın olumlu etkileri yönünden meme ve mide kanserli hasta-lar arasında fark bulunmadı.