Prolactin levels in patients with pemphigus

Abstract

Background and Design: It has been demonstrated that prolactin has an important role in autoimmunity and autoimmune diseases. The aim of this study was to evaluate the level of prolactin (PRL) in pemphigus patients and its relation with the disease and disease activity. MATERIALS-METHODS: Serum PRL levels were determined by immunoassay methods in 44 patients with pemphigus and in control group of 44 individuals. RESULTS: Hyperprolactinemia was 10.2% for pemphigus patients versus 0% for healthy controls (p= 0.058). Serum PRL levels of the male patients was not significantly enhanced compared with that found in controls (p>0.05) while the female patients' was statistically significantly increased (p

Özet

Prolaktinin (PRL) otoimmünite ve otoimmün hastalıklarla ilişkili olduğu gösterilmiştir. Bu çalışmada otoimmün bir hastalık olan pemfigusta serum PRL düzeylerinin hastalık ve hastalık aktivitesi ile ilişkisini saptamak amaçlandı. Pemfigus tanısı alan 40 hasta ile 44 kişiden oluşan kontrol grubunda serum PRL düzeyleri immünoassay yöntem ile ölçüldü. Hiperprolaktinemi, pemfiguslu hastalarda %10.2, kontrol grubunda %0 olarak saptandı (p=0.058). Erkek hastalarda serum PRL düzeyleri kontrol grubuna göre anlamlı olarak yüksek bulunmazken (p>0.05), kadın hastalarda anlamlı derecede yüksek bulundu (p