Evaluation of biochemical parameters and oxidative stress in sheep naturally infected with Dicrocoelium dendriticum and hydatid cysts

Abstract

The purpose of the study was to investigate the lipid peroxidation and antioxidant status as well as biochemical profile in sheepnaturally infected with Dicrocoelium dendriticum and hydatid cysts. Ten sheep naturally infected with D. dendriticum, 10 sheep naturallyinfected with hydatid cysts, and 10 healthy sheep were used. The blood and visceral organs of sheep brought to a slaughterhouse in theregion of Kırıkkale were checked for D. dendriticum and hydatid cysts. Plasma total protein, albumin, total bilirubin, total cholesterol,Ca, Mg, inorganic P, Cu, Zn, vitamin A, vitamin C, vitamin E, β-carotene, AST, ALT, GGT, ALP, erythrocyte MDA levels, and SODand CAT activities were detected. Erythrocyte MDA, plasma total bilirubin levels, and AST and ALP activities were increased whiletotal protein and vitamin A levels were decreased in sheep infected with parasites. Erythrocyte SOD activities were decreased in D.dendriticum group, and CAT activities were decreased in the hydatid cyst group and D. dendriticum group. Total bilirubin levels wereincreased and total protein levels were decreased in sheep infected with parasites. These results suggest that endoparasitic infectionssuch as D. dendriticum and hydatid cysts cause oxidative stress and change some biochemical parameters in sheep.