Hemolytic uremic syndrome and IgA nephropathy in a child: Coincidence or not?

Abstract

Sürmeli-Döven S, Delibaş A, Gürses İ, Kayacan UR, CoşkunYılmaz B, Esen K, Korkmaz E, Özaltın F. Hemolytic uremic syndrome and IgAnephropathy in a child: Coincidence or not? Turk J Pediatr 2018; 60: 81-85.A previously healthy 18-month old boy, presenting with diarrhea, anemia,thrombocytopenia and acute renal failure was admitted to our hospital.Hemolytic uremic syndrome (HUS) was diagnosed with his clinical andlaboratory findings. His stool was negative for Shiga toxin producing E. coli (STEC).During follow-up he developed respiratory distress, hypertrophic cardiomyopathy andseizure. His genetic tests for atypical HUS (aHUS) were negative. His clinical andhistological findings indicated hemolytic uremic syndrome and immunglobulinA nephropathy (IgAN). The patient responded to steroid treatment andplasma exchange therapy with peritoneal dialysis. We discuss the probableconnection between HUS and IgAN.