Journals / Turkish Journal of Obstetrics and Gynecology / 2020 / Cilt: 17 - Sayı: 1
Evaluation of second-trimester maternal serum betatrophin levels and lipid and carbohydrate metabolism parameters in patients with gestational diabetes mellitus
- Pages
- 28–33
- DOI
- —
Abstract
Objective: We investigated the role of betatrophin in the etiopathogenesis of gestational diabetes mellitus (GDM) and its association with lipid andcarbohydrate metabolism in patients with GDM and normoglycemic pregnant women.Materials and Methods: A total of 60 patients [30 pregnant women with GDM (study group) and 30 healthy age-, body mass index-, and gestational agematched pregnant women (control group)] were included in this study. Serum betatrophin, fasting glucose, insulin, glycated hemoglobin A1c (HbA1c),and C-peptide levels, as well as lipid parameters, were measured.Results: Serum betatrophin, fasting glucose, HbA1c, insulin, and C-peptide levels were significantly higher in the GDM group than in the control group(p
Özet
Amaç: Bu çalışmada betatropinin gestasyonel diabetes mellitus (GDM) etiyopatogenezindeki rolünü ve GDM ile komplike ve normoglisemik gebe kadınlarda betatropinin lipid ve karbonhidrat metabolizması ile ilişkisini araştırdık. Gereç ve Yöntemler: Çalışmaya toplam 60 hasta [GDM tanısı konmuş 30 gebe (çalışma grubu) ve 30 sağlıklı yaş, vücut kitle indeksi- ve gebelik haftası eşleştirilmiş gebe (kontrol grubu)] alındı. Serum betatropin, açlık glukozu, insülin, glikolize hemoglobin A1c (HbA1c), C-peptid düzeyleri ve lipid parametreleri ölçüldü. Bulgular: Serum betatropin, açlık glukozu, HbA1c, insülin ve C-peptid düzeyleri GDM grubunda kontrol grubundan anlamlı olarak daha yüksekti (sırasıyla; p