Journals / Turkish Journal of Medical Sciences / 1998 / Cilt: 28 - Sayı: 6
Distribution of Tamoxifen in Rat Tissues During Steady-State Treatment
- Pages
- 591–594
- DOI
- —
Abstract
Tamoxifen citrate (TAM), a nonsteroidal antiestrogen, is a drug of choice in the endocrine treatment for all stages of breast cancer in both pre and postmenopausal patients. The tissue distrubution of TAM alone and combined with medroxyprogesterone acetate (MPA) following long-term p.o. administration in immature rats is investigated in the present study. The highest consentrations of TAM has been found in the hypophysis in both groups. TAM consentrations were effected by MPA treatment in the liver and kidneys.
Özet
Tamoxifen citrate (TAM), a nonsteroidal antiestrogen, is a drug of choice in the endocrine treatment for all stages of breast cancer in both pre and postmenopausal patients. The tissue distrubution of TAM alone and combined with medroxyprogesterone acetate (MPA) following long-term p.o. administration in immature rats is investigated in the present study. The highest consentrations of TAM has been found in the hypophysis in both groups. TAM consentrations were effected by MPA treatment in the liver and kidneys.