Antitumor effects of TNF-beta, 5-FU and their combinations on cervical carcinoma cell lines

Abstract

Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-beta showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-beta on both cell lines.