8-Hydroxy-2’-deoxyguanosine as a biomarker of oxidative stress in acute exacerbation of chronic obstructive pulmonary disease

Abstract

Background/aim: 8-Hydroxy-2’-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in manydiseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronicobstructive pulmonary disease (AECOPD).Materials and methods: A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in thestable phase, and 110 AECOPD patients. Peripheral blood samples, demographic information, and clinical characteristics were collectedfrom all subjects at the time of being recruited into the study. Plasma 8-OHdG level was detected by enzyme-linked immunosorbentassay.Results: 8-OHdG was increased in patients with AECOPD compared to healthy subjects and patients with stable COPD, especially insmokers. It also increased with the GOLD stage, mMRC grade, CAT score, and group level of combined COPD assessment. Additionally,further analysis revealed that 8-OHdG was negatively correlated with FEV1, FEV1% predicted, and FEV1/FVC and positively correlatedwith C-reactive protein, procalcitonin, and neutrophil CD64.Conclusion: 8-OHdG is associated with spirometric severity, symptomatic severity, exacerbation risk, and inflammatory biomarkers inAECOPD patients, suggesting it as a promising biomarker for reflecting disease severity and guiding the choice of optimal therapeuticdecision.