Viral prevalence, clinical profiles and comparison of severity scores for predicting the mortality of adults with severe acute respiratory infections

Abstract

Background/aim: The aim of this study was to determine the accuracy of severity scores for predicting the 28-day mortality amongadults with severe acute respiratory infection (SARI) admitted to the emergency department.Materials and methods: This study included 159 consecutive adult patients with SARI admitted to the emergency department of atertiary hospital. A standard form was filled out in order to record demographic information, clinical parameters, laboratory tests, andradiographic findings of the patients. CURB-65, PSI, SIRS, qSOFA, SOFA and APACHE II scores were compared between the survivorand nonsurvivor groups.Results: Of 159 patients included in the study, 38.4% were positive for respiratory viruses and 28.3% were positive for influenza viruses.35.8% of the patients were admitted to an intensive care unit (ICU) and the mortality rate was 36.5%. The area under the receiveroperating characteristic curve of CURB-65, PSI, SIRS criteria, qSOFA, SOFA and APACHE II scores were 0.717, 0.712, 0.607, 0.683,0.755, and 0.748, respectively in predicting mortality and 0.759, 0.744, 0.583, 0.728, 0.741, and 0.731, respectively in predicting ICUadmission.Conclusion: SOFA and APACHE II were more accurate than SIRS in predicting the 28-day mortality among adults with SARI. Therewas no significant difference among these scores in terms of other multivariate comparisons.