Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

Rukiye NAR, Hande ŞENOL, Gülsüm AKGÜN ÇAĞLIYAN, Başak ÜNVER KOLUMAN, Nilay ŞEN TÜRK, Sibel HACIOĞLU, Kadir İLKKILIÇ, Mehmet Nuri BAŞER, Aslı BOZDEMİR, Veysel EROL, Onurcan YILDIRIM, Ömer ÇAĞLIYAN, Nil GÜLER

Abstract

Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1–190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (≥ 2) or low ( 1 (HR = 2.04, p = 0.006), stage IIIA–IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age ≥ 65 years (HR = 2.02, p = 0.007), stage IIIA–IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters. Conclusion: High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL. Key words: Lymphoma, Controlling Nutritional Status score, survival, prognosis