The relationship between serum NT-proBNP levels and severity of coronary artery disease assessed by SYNTAX score in patients with acute myocardial infarction

Abstract

Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is ameasure of the complexity of coronary artery disease.Materials and methods: We enrolled 405 consecutive patients with myocardial infarction who underwent coronary angiographicexamination. Patients were divided into 3 groups according to their SYNTAX scores. Those with SYNTAX score ≤22 were included inthe low SYNTAX score group (LSTX), those with a score of 23–32 were included in the intermediate SYNTAX score group (ISTX), andthose with a score of ≥33 were included in the high SYNTAX score group (HSTX).Results: NT-proBNP levels were found to be significantly higher in the HSTX group compared to the other groups (P < 0.001) and inthe ISTX group compared to the LSTX group (P < 0.001). The NT-proBNP levels demonstrated an increase from low SYNTAX score tohigh SYNTAX score tertiles.Conclusions: NT-ProBNP levels in patients with myocardial infarction on admission were independently associated with extent,severity, and complexity of coronary atherosclerosis as assessed by SYNTAX score.