Journals / Turkish Journal of Endocrinology and Metabolism / 2019 / Cilt: 23 - Sayı: 4
Evaluation of Paraoxonase1 Polymorphisms in Hypothyroid Patients and Their Relationship with Paraoxonase Activity and Serum Lipids
- Pages
- 213–221
- DOI
- —
Abstract
Objective: The risk for atherosclerosis increases in hypothyroidism, although its associated mode of pathogenesis has not been determined yet. Paraoxonase1 (PON1) is an enzyme that is antioxidative and antiatherogenic. This study was planned to determine distributions of PON1 192 and 55 gene polymorphisms in hypothyroid patients and healthy individuals and to investigate the effects of these polymorphisms on PON1 activity and serum lipids. Material and Methods: Seventy-five primary hypothyroid patients and 45 healthy volunteers were recruited into the study and PON1 192 and 55 gene polymorphisms, serum PON1 activity, and lipid profiles were measured in them. Results: The activity of PON1 declined in the recruited patients compared to that in the control group (p
Özet
Amaç: Hipotiroidizmde ateroskleroz riskinin arttığı bilinmesine rağmen, hipotiroidizmdeki aterosklerozun patogenezi henüz tam olarak açıklanamamıştır. Paraoksonaz1 (PON1), antioksidan ve antiaterojenik etkileri olduğu bilinen bir enzimdir. Bu çalışma, hipotiroidili hastalarda ve sağlıklı bireylerde PON1 192 ve 55 gen polimorfizmlerinin dağılımını belirlemek ve bu polimorfizmlerin PON1 aktivitesi ve serum lipidleri üzerine etkilerini araştırmak için planlandı. Gereç ve Yöntemler: Çalışmaya 75 primer hipotiroidi hastası ve 45 sağlıklı gönüllü dâhil edildi. PON1 192 ve 55 gen polimorfizmleri, serum PON1 aktivitesi ve lipid profilleri ölçüldü. Bulgular: Hastalarda PON1 aktivitesi kontrol grubuna göre düşüktü (p