Image reconstruction for frequency-domain diffuse optical tomography

Abstract

The image reconstruction algorithm of diffuse optical tomography (DOT) is based on the diffusion equationand involves both the forward problem and inverse solution. The forward problem solves the diffusion equation usingthe finite element method for calculating the transmitted light distribution under the condition of presumed light sourceand optical coefficient. The inverse solution reconstructs the optical property coefficient distribution using Newton’smethod. The work within this study develops an image reconstruction algorithm for frequency-domain DOT. A numericalsimulations approach to light propagation in the tissue is conducted, while the optical property is reconstructed employingdata around the boundary. We implement different designated simulation cases, including different contrast ratios ofabsorption and reduced scattering coefficient of inclusion with respect to the background used for verifying the resultsof the forward problem and the developed reconstruction algorithm. Reconstruction results indicate that the quality ofreconstructed images can be effective for screening breast cancer.