Voltammetric determination of famotidine on a disposable pencil graphiteelectrode

Abstract

The present paper describes the use of a disposable pencil graphite electrode (PGE) for the voltammetric de-termination of famotidine. Cyclic voltammetric studies using different supporting electrolytes emphasized an irreversibleoxidation of famotidine on the PGE. The electrode process is diffusion-controlled and pH-dependent. Differential pulsevoltammetry (DPV) in phosphate buffer solution of pH 6.81 was employed for famotidine's quantitative determination.The anodic peak current of famotidine varies linearly with the analyte concentration in the range 4.72 107{4.95 104M. Detection and quanti cation limits were 1.51 107M and 5.04 107M famotidine, respectively.The developed DPV method using the inexpensive, disposable PGE was successfully applied to the simple and rapiddetermination of famotidine from pharmaceuticals.