Synthesis and antimicrobial and antioxidant activities of hybrid molecules containing benzotriazole and 1,2,4-triazole

Abstract

Eleven novel 1,2,4-triazolylbenzotriazoles have been prepared using 1-(hydrazinylcarbonylmethyl)-1H -benzotriazole (3) as a potent intermediate. Compound 3, however, was obtained from benzotriazole in two steps. All synthesizedcompounds were characterized by detailed spectral studies like IR, 1 H NMR, 13 C NMR, and mass spectrometry. Allsynthesized compounds were evaluated for their in vitro antimicrobial activity against seven strains of bacteria andfour strains of fungi. Compounds 13, 17, 19, 20, and 21 were found to possess antibacterial activity comparable tothat of ciprofloxacin against a Klebsiella pneumoniae strain. Except for compounds 2 and 13, all compounds showedgood antifungal activity against an Aspergillus niger strain as compared to miconazole. The synthesized compoundswere also evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and the results areencouraging, especially for compounds 3, 20, and 21.