Tetrahydropyridine: a promising heterocycle for pharmacologically active molecules

Abstract

The tetrahydropyridine (THP) ring system has received considerable focus due to its excellent ability to actas a pharmacophore. It is recognized as a major constituent in natural alkaloids. THP derivatives have been reportedfor a diverse range of biological activities. Recent synthetic works contain syntheses of monosubstituted, disubstituted,trisubstituted, highly functionalized, and condensed structures. In this review, we summarize the recent literature dealingwith the bioactive nature of this important heterocycle.