Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

Abstract

An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL- b -MPEG), composedof hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)- b -poly(ε-caprolactone) diblock polymers (MPEG- b -PCL) as the shell building block, was designed. The synthesizedpolymers were characterized with FTIR, 1 H NMR, 13 C NMR, and GPC analysis. Monodisperse HPAE-PCL- b -MPEG nanoparticles with dimensions of