Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis

Abstract

Objectives. Many systemic diseases including cardiovascular disturbances have been described in psoriaticpatients. In the previous studies, left ventricle (LV) subclinical myocardial dysfunction was reported in thepsoriasis patients. The T-wave peak to end (Tp-e) interval is a relatively new marker for ventriculararrhythmogenesis and repolarization heterogeneity. Prolongation of this interval represents a period of potentialvulnerability to ventricular arrhythmias. However, there is no information available assessing the Tp-e intervaland related calculations in patients with psoriasis disease. The aim of this study was to evaluate ventricularrepolarization in patients with psoriasis disease by using QT, corrected QT (QTc) and Tp-e interval, Tp-e/QTratio, and Tp-e/QTc ratio. Methods. In this study, retrospective analysis of 30 patients who underwent thepsoriasis treatment and of 30 healthy individuals was performed. The severity of the disease was evaluated bythe "Psoriasis Area and Severity Index". QT, corrected QT (QTc), Tp-e interval and Tp-e/QT ratio weremeasured by means of the 12-lead electrocardiogram. Left ventricular function was evaluated byechocardiography. Results. Baseline characteristics and QT and QTc intervals were similar in both groups. Nodifference was detected between the groups with regards to Tp-e interval (83.0±9 vs 82.3±10; p=0.81), Tpe/QT (0.22±0.03 vs 0.23±0.04; p=0.3) and Tp-Te/QTc (0.20±0.04 vs 0.19±0.04; p=0.77). Conclusions. Thesefindings suggest that ventricular repolarization in mild to moderate psoriasis patients might be unimpaired.Larger samples and severe degree psoriasis patients are needed to evaluate the arrhythmia risk in psoriasis patients.