A challenging palliation via novel therapeutic approach for unusual presenting with gingival metastasis from renal cell carcinoma relapsed eight years after nephrectomy

Abstract

Renal cell carcinoma (RCC) is the third most frequently seen primary source of metastatic lesions of the oralcavity. Still oral cavity metastasis is a rarely seen clinical manifestation during the course of RCC. In a patientwith a known history of RCC, in the presence of newly emerged oral and maxillofacial lesion(s), possibilityof metastasis should be always thought of and pathological investigation should be performed as soon aspossible. In RCC, metastatic involvement of oral cavity is generally accompanied by involvement of otherorgans with resultant lower chance of cure and poor prognosis. Especially in conditions which adversely affectfunctions of chewing and swallowing consequently nutrition and quality of life, surgery is contraindicated andlocal interventional methods transarterial chemoembolization, microwave ablation and radiofrequency ablationcan be good palliative treatment alternatives. In advanced stages of the diseases with systemic involvementapplication of local interventional methods either solely or in combination with radiotherapy and surgeryincreases compliance to the systemic treatment and can contribute markedly to the prolongation of survival.Herein we aimed to present a case with unusual histopathological characteristics and presentation in whom weachieved a longer period of disease-free survival using a different local treatment method.