Inflammation-related cancer or cancer-related inflammation

Abstract

Inflammation is the body’s defensive action against various stimuli such as physical or chemical or infectiousagents. Acute inflammation and their mediators help in tissue repair and healing. If the inflammation aggravateschronically, non-resolved, dysregulated immune system, results release of various inflammatory mediatorssuch as free radicals (ROS and RNS), cytokines, chemokines, growth factors and proteolytic enzymes producedby innate and adaptive immune cells activate transcriptional factors (NF-KB,STAT3 and HIF-1α) results incell proliferation, angiogenesis, immunosuppression, genetic instability, invasion and metastasis. Oncogenesrelated to cancer activate inflammatory mediators such as chemokines and cytokines, which alters theinflammatory tumor microenvironment, promotes tumor progression. This article highlights about the role ofinflammation and oncogenes activate inflammatory mediators in tumor progression