Frequency and predictors of access site complications of the transfemoral diagnostic coronary procedures

Abstract

Objectives: Access site complications (ASC) remain important and common adverse events after coronaryangiography. The aim of this study was to evaluate the frequency and predictors of ASC in patients undergoingdiagnostic coronary angiography (DCA) via the femoral artery.Methods: In this prospective analytical cross sectional study, DCA was performed in 3972 patients bytransfemoral approach. The femoral access site hemostasis was obtained by manual compression in all patients.Demographic characteristics of the patients, size of the arterial sheaths, duration of compression time, patientsblood pressure, medications, hemoglobin and platelet levels were recorded. All patients were evaluated forASC (pseudoaneurysm, bleeding, dissection, hematoma). The ASC rate was calculated and ASC predictorswere determined by multivariate analysis.Results: The ASC rate was 1.3% (53 of 3972 patients). The complications were more frequent in female(female: 29 of 53 [54.7%] vs male: 24 of 53 [45.3%]; p = 0.007) and chronic renal failure (CRF) patients (103of 3919 [2.6%] vs 4 of 53 [7.5%]; p = 0.02). Hemoglobin level was lower (13.40 ± 1.73 vs 12.86 ± 1.75; p =0.02) and manual compression time was longer (9.19 ± 3.28 min vs 14.53 ± 6.47 min; p < 0.001) in the ASCgroup. Clopidogrel (188 of 3919 [4.8%] vs 7 of 53 [13.2%]; p = 0.005) and low molecular weight heparin(LMWH) using were more frequent (37 of 3919 [0.9%] vs 7 of 53 [13.2%]; p < 0.001) in the ASC group.According to multivariate analysis; female gender; OR: 2.13, 95% CI: 1.14-3.99 (p = 0.017), presence of CRF;OR: 3.15, 95% CI: 1.06-9.29 (p = 0.038), manual compression time; OR: 1.23, 95% CI: 1.17-1.30 (p < 0.001)and LMWH using; OR: 15.68, 95% CI: 6.05-40.61 (p < 0.001) were predictors of ASC.Conclusions: The incidence of femoral ASC rate was 1.3% in patients with DCA. Female gender, presence ofCRF, using LMWH and long manual compression time were predictors of ASC.