Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population

Abstract

Objectives: Factor VII has a crucial role in the extrinsic coagulation pathway and initiates the thrombusformation. Some studies showed that high plasma factor VII level was related to increased acute myocardialinfarction (AMI) risk. But, some studies were reported opposite findings. Some polymorphisms can changethe factor VII level. There is limited information about factor VII polymorphisms in southern Turkey population.Our aim was to determine the frequencies of Factor VII-401 and -402 polymorphisms and their relation toAMI in southern Turkey area.Methods: We enrolled 83 patients with AMI and 71 healthy subjects. Routine laboratory tests and factor VII401 and -402 polymorphisms were determined from blood samples. Factor VII -401 and -402 polymorphismswere analyzed by LightCycler device using Real-Time PCR technique.Results: Family history of coronary artery disease and smoking frequencies were higher in patients group (p< 0.001 and p = 0.013, respectively). Patients had higher LDL cholesterol (p = 0.011) level, and lower HDLcholesterol (p = 0.025) level compared to healthy subjects. Factor VII-401 and -402 polymorphism genotypeswere not significantly different in both groups. Also allele frequencies were similar in both groups.Conclusion: Factor VII-401 and -402 polymorphisms do not seem to increase AMI risk in southern Turkey.