Investigation of Genotoxic, Antimicrobial and Antioxidant Activities of Leaf and Flower Extracts of Cynara syriaca Boiss

Abstract

The mutagenicity and antimutagenicity of leaves and flower extract of Cynara syriaca Boiss were studied with Amesassay in Salmonella typhimurium TA98 and TA100 strains. While leaves extract did not show any mutagenic effectsagainst all the tester strains with or without metabolic activation, the flower extract showed mutagenic effect against TA98strain without metabolic activation. On the other hand, it has been observed that the extracts have antimutagenic activityagainst mutations induced by sodium azide and daunomycin. The antimicrobial activity of extracts was determined bydisc diffusion and MIC value. Both of the extracts possess weak antimicrobial activity. Cupric reducing antioxidantcapacity (CUPRAC), DPPH free radical scavenging activity, and ABTS radical cation decolorization methods werecarried out to determine the antioxidant activity. Among the tested antioxidant methods, the highest antioxidant capacitywas determined in ABTS radical cation decolorization assay in which both of the extracts exhibited the best effect.Flower extract exhibited higher activity also in DPPH free radical scavenging