Incidence and risk factors of contrast-induced nephropathy after diagnostic or interventional coronary angiography

Abstract

Objectives. Contrast-induced nephropathy (CIN) is the third most common cause of acute renal failure thatoccurred in the hospital. In Turkey, there is not enough data about the frequency of CIN in cardiologicalinterventions. Increased contrast volume and creatinine value are related with CIN. We also investigated theCIN predictors. Methods. A total of 2604 patients who underwent coronary angiography or percutaneouscoronary intervention (PCI) in our hospital were prospectively evaluated in terms of CIN. The definition ofCIN includes absolute (≥0.5 mg/dl) or relative increase (≥25%) in serum creatinine at 48-72 h after exposureto a contrast agent compared to baseline serum creatinine values. Results. CIN was detected in 13.6% (355patients) of 2604 patients. According to the procedure; CIN rate was 13.3% (280 of 2108 patients) in coronaryangiography, 13.08% (50 of 382 patients) in elective PCI and 21.49% (25 of 114 patients) in primary PCI.Compared with each of these three groups patients, CIN rate was significantly higher in primary PCI groupthan coronary angiography (p=0.009) and elective PCI (p=0.02) groups. In multivariate analysis, age (oddsratio [OR]=1.04; 95% confidence interval [CI], 1.02-1.06; p