Assessment of the Fatigue with Biochemical Data and Corpus Callosum Atrophy in Multiple Sclerosis Patients

Abstract

Objective: Fatigue is a common finding in patients with multiple sclerosis (MS) and its etiopathogenesis has not been fully elucidated. The aim of this study was to evaluate the relationship between fatigue and biochemical data and corpus callosum index (CCI) in brain magnetic resonance imaging (MRI). Methods: In this cross-sectional study, 100 individuals (58 MS patients and 42 control sub- jects) were included. The disability of the patients was determined with the extended disabil- ity status scale (EDSS), and their fatigue was evaluated with the Fatigue Severity Scale (FSS). Biochemical data were analyzed. CCI values were calculated on brain MRI scans. Results: There was no difference between the groups in terms of age, gender, and BMI (p>0.05). In MS patients, folate level and CCI values were found to be statistically significantly lower compared to the control group (p=0.029 and p