Causes of Nondiabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

Abstract

Objective: The aim of this study is to evaluate the contribution of kidney biopsy performed with an appropriate indication to diagnosis and treatment in diabetic patients with nephropathy with a single-center experience. Methods: In our study, 32 patients with type 2 diabetes who underwent kidney biopsy in our hospital between 2012 and 2019 were included. Kidney biopsy indications were determined as patients with diabetes without diabetic retinopathy and with proteinuria above 1 g/day. Results: Diabetic nephropathy (DN) and nondiabetic nephropathy (NDN)were diagnosed with renal biopsy. In 14 of 32 patients, NDN was reported in histopathological evaluation. Membranous nephropathy was detected in 4 of these patients, focal segmental glomerulosclerosis (FSGS) in other 4 patients, light chain disease in 2 patients, IgA nephropathy in 2 patients, minimal change nephropathy in 1 patient, and finally AA amyloid in 1 patient. Nondiabetic renal disease superimposed on DN (DN + interstitial nephritis and DN + FSGS) was observed in two patients. In 16 diabetic patients, DN was detected by renal biopsy. Conclusion: We believe that for diabetic patients, it may be important to distinguish nondiabetic kidney disease from diabetic kidney nephropathy, to choose proper treatment methods and determine kidney prognosis.