Composite Mantle Cell Lymphoma and EBV Positive Classical Hodgkin Lymphoma: A Case Report

Abstract

Composite lymphomas are two different lymphomas existing in the same location, syn- chronously. In the literature, composite lymphomas developed from different clones are rarely found as case reports. The coexistence of mantle cell lymphoma and classical Hodgkin lymphoma (HL) is very uncommon. The case we present was a 53-year-old male patient with a lymphocyte-rich HL in the left inguinal lymph node biopsy and a mantle cell lymphoma in the bone marrow. The diagnosis was composite lymphoma (mantle cell lymphoma + lym- phocyte-rich HL) in the re-evaluation of the lymph node biopsy. Our case shows composite lymphoma developing from two separate clones (EBV positive classical HL and mantle cell lymphoma) in the lymph node and mantle cell lymphoma in the spleen and bone marrow. This case was presented and discussed because of its rarity and misleading morphology and because it is the youngest biclonal composite lymphoma with the longest survival.