Overview of Anti-VEGF Treatment Regimens and New Agents in Age-Related Macular Degeneration

Abstract

Age-related macular degeneration (AMD), which can result in central vision loss, is among the leading causes of blindness world wide. The beginning of the anti-vascular endothelial growth factor (anti-VEGF) era has revolutionized the treatment of AMD. The efficacy of anti-VEGFs (bevacizumab, ranibizumab and aflibercept) has been proven in important clinical studies such as ANCHOR, MARINA and VIEW, leading to the widespread use of these agents in the treatment of AMD. This review focuses on important clinical studies using 3 anti-VEGF agents and their link with real-world evidence including data point specific to our country. Also, the efficacy of anti-VEGF agents and real-life treatment regimens will be reviewed. New treatments under development in the search for the ideal agent for AMD treatment will also be discussed.