Copper-free Sonogashira cross-coupling reactions catalyzed by an efficient dimericC,N-palladacycle in DMF/H2O

Abstract

Very small concentrations of a dimeric C,N-palladacycle were used as an efficient homogeneous catalyst forSonogashira cross-coupling reactions between various aryl halides and phenylacetylene. The catalytic reactions wereperformed without the need for copper in DMF/H2O. This catalytic system shows excellent yields for aryl iodides andbromides and even in the case of aryl chlorides.