Journals / Molecular Imaging and Radionuclide Therapy / 2019 / Cilt: 28 - Sayı: 1
The Correlation of Clinicopathological Findings and Neutrophil-toLymphocyte and Platelet-to-Lymphocyte Ratios in Papillary Thyroid Carcinoma
- Pages
- 15–20
- DOI
- —
Abstract
Objectives: Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recently introduced as potential biomarkers for tumor pathogenesis, development and prognosis in solid tumors. Our aim was to assess the correlation of clinicopathological features and NLR and PLR in patients with papillary thyroid carcinoma (PTC). Methods: A total of 201 papillary thyroid carcinoma patients were divided into groups with a cut-off preoperative median NLR and PLR value of 1,92 and 123.9, respectively. The correlation of NLR and PLR and clinicopathological features including age, tumor size, extra-thyroidal extension, thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality of the patients were analyzed. Results: The mean NLR and PLR were 2.11±0.94, 129.69±42.81, respectively. Larger tumor size and higher positivity of extra-thyroidal spread were correlated with higher NLR values. No significant relationship was found between NLR and age, presence of thyroid capsule invasion, surgical margin positivity, multifocality, bilaterality, and lymph node metastasis. Also no significant association was observed between the clinicopathological features and PLR. Conclusion: High NLR was found to correlate with tumor size and extra-thyroidal extension. NLR may be used as a marker to determine the clinical behavior of disease in patients with papillary thyroid carcinoma (PTC).
Özet
Amaç: Son yıllarda nötrofil/lenfosit oranı (NLO) ve trombosit/lenfosit oranı (TLO) gibi enflamatuvar belirteçlerin solid tümör patogenezinde, gelişmesinde ve prognozunda etkili olduğuna dair çalışmalar mevcuttur. Bu çalışmada tiroid papiller kanserinin (PTK) kliniko-patolojik özellikleri ile NLO ve TLO arasındaki ilişkinin retrospektif olarak incelenmesi amaçlanmıştır. Yöntem: Çalışmaya dahil edilen 201 hasta preoperatif medyan NLO (grup 1 0,05). Sonuç: Çalışmamız PTK de NLO ile tümör boyutu ve ekstra-tiroidal yayılım arasında istatistiksel olarak anlamlı ilişki bulunduğunu göstermektedir. NLO’nun diğer bazı solid tümörlerde olduğu gibi PTK olgularında hastalığın klinik davranışını belirlemek için yararlı bir belirteç olarak kullanılabileceği düşünülmektedir.