Incidence of gestational trophoblastic disease in Tokat province, Turkey

Abstract

Objective: This study investigated the incidence of gestational trophoblastic disease (GTD) in Tokat province, Turkey. Material and Methods: The medical records of patients who had been diagnosed and treated at one university hospital, six government hospi- tals, and one specialist hospital in Tokat province between January 2005 and December 2012 were evaluated retrospectively. Results: During the study period, there were 59,754 births and GTD was diagnosed in 73 cases. The calculated GTD incidence was 1.22/1000. The mean age of the patients diagnosed with GTD was 28.6±7.3 (range 17-51) years. In GTD, complete moles occurred in 26%, partial moles in 74%, and no invasive moles, choriocarcinomas, or placental site trophoblastic tumours were found. Only two patients received chemotherapy (methotrexate). There was no mortality associated with the disease during follow-up. Conclusion: The incidence of GTD in Tokat province was 1.2 per 1000 births. Early diagnosis, treatment, and follow-up play a critical role in preventing the morbidity and mortality associated with disease. The incidence of GTD, which has a high recovery rate with adequate treatment and follow-up, can be determined from regional and community-based research.