Preeklamside plasma homosistein ve nitric oksit seviyeleri

Abstract

Objective: Endothelial dysfunction, which is associated with decreased nitric oxide (NO) and hyperhomocysteinemia, is an essential component of preeclampsia Aim of our study was to investigate nitric oxide levels and homocysteine levels in preeclamptic women and to study the relationship between homocysteine and NO. Material and Method: Thirty preeclamptic and thirty healthy pregnant women above 30 gestational weeks were included to study. Venous blood samples were collected from all women before administration of any drug. Homocysteine and two stable oxidation products of NO, nitrate and nitrite were analyzed in healthy pregnant women, mild preeclamptic, severe preeclamptic and eclamptic women. Results: Demographical and obstetrical characteristics of patients were similar, except blood pressure measurements. Mean of homocysteine values were significantly higher in preeclamptic women (9.0±3.4 μmol/l) than healthy controls (5.3±1.3 μmol/l). Homocysteine levels were found to be increased as the severity of preeclampsia increased; with highest level in eclamptic patients (14.0±1.8 μmol/l, p

Özet

Amaç: Nitrik oksit azalması ve hiperhomosisteinemi ile ilişkili olan endotelial disfonksiyon preeklampsinin temel unsudur. Çalışmamızın amacı preeklamptik gebelerde nitrik oksit ve homosistein seviyelerini çalışmak, homosistein ile nitrik oksit arasındak ilişkiyi incelemekti. Gereç ve Yöntemler: Çalışmaya 30. gebelik haftasından büyük eylemde olmayan 30 preeklamptik ve 30 sağlıklı gebe dahil edilmiştir. Venöz kanlar her hangi bir ilaç verimeden önce toplanmış. Homosistein ile nitrik oksitin iki kalıcı yıkım ürünü olan nitrit ve nitrat sağlıklı gebeler, hafif preeklamptik gebeler, şiddetli preeklamptik gebeler ve eklampsili gebelerde çalışılmıştır. Bulgular: Kan basıncı ölçümleri dışında hastaların obstetrik ve demografik özellikleri benzerdi. Preeklamptik kadınların serum homosistein ortalaması (9.0±3.4 μmol/l) sağlıklı kontrollerden (5.3±1.3 μmol/l) daha yüksekti (p