Journals / Journal of the Turkish-German Gynecological Association / 2018 / Cilt: 19 - Sayı: 3
Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations
- Pages
- 128–131
- DOI
- —
Abstract
Objective: The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.Material and Methods: For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performedon blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL,USA) was used.Results: A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and controlgroups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group.Conclusion: The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developinguterine leiomyoma. (J Turk Ger Gynecol Assoc 2018; 19: 128-31)