Comparing perioperative vaginal misoprostol with intraoperative pericervical hemostatic tourniquet in reducing blood loss during abdominal myomectomy: A randomized controlled trial

Abstract

Objective: To compare the effectiveness of perioperative vaginal misoprostol with intraoperative pericervical hemostatic tourniquet in reducingblood loss during abdominal myomectomy.Material and Methods: A randomized controlled trial involving women with uterine leiomyoma who underwent abdominal myomectomywas conducted at a tertiary facility in Nigeria. Participants were recruited after they gave informed consent and randomized into group I (singledose 400 μg vaginal misoprostol one-hour before surgery) and group II (intraoperative pericervical hemostatic tourniquet). Eighty participants (40in each group) were recruited. Uterine size was measured in centimeters above the pubic symphysis, and blood loss estimation involved directvolume measurement and gravimetric methods. The main outcome measures were intraoperative blood loss, blood transfusion, and recourseto hysterectomy. Ethical approval and trial registration were obtained; the data were analyzed using the SPSS software version 21.0; p