A Novel One-Pot Green Synthesis and Characterization of 5- Substituted Bis-Iminothiazolidinones

Abstract

In this study, some new 5-substituted bis-iminothiazolidinone derivatives have been synthesizedvia one-pot green synthesis. The study comprises two steps. In the first step, bis-thioureas were preparedby the reaction of aryl isothiocyanates with substituted amines. In the second step, substituted bisthioureasprepared beforehand and chloroacetic acid were condensed with substituted thiophene-2-carboxaldehydes and new 5-substituted bis-iminothiazolidinone compounds were obtained. The structuresof all these synthesized compounds were determined and characterized by infrared, nuclear magneticresonance and mass spectral data.