Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Abstract

In this work, 15 different coumarin hydrazides were successfully synthesized andscreened for their antioxidant and antilipase activities. To do this, firstly, salicylaldehydederivatives and Meldrum's Acid were reacted in absolute ethanol with catalytic amount ofpyridine to obtain coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds weretreated with 1H-benzotriazole in dichloromethane by using thionyl chloride to synthesizebenzotriazole derivatives (2a-e). Then, compounds 2a-e were reacted with three commercialhydrazides (nicotinic hydrazide, benzhydrazide,and phenyl acetichydrazide) in ethanol by usingmicrowave irradiation and conventional heating procedures to obtain final products (3-5a-e).Finally, these compounds were tested for their anti-oxidant and anti-lipase activities. Thestructure of newly synthesized compounds was identified by IR, 1H NMR, 13C NMR, and elementalanalysis data.