Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water

Abstract

In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which isused for the treatment of hypertension, using $H2O2$ as the oxidizing agent in subcritical water as a medium.Response surface methodology was applied to optimize experimental parameters such as temperature,treatment time, and concentration of the oxidizing agent. The highest TOC removal was obtained as85.22% in 147.3 minutes of treatment time at 403 K using 80 mM of hydrogen peroxide. The reliability ofthe performed method was evaluated by ANOVA and the theoretical equation of TOC removal ofhydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than0.0001, respectively.