Spectral, Thermal and In Vitro Antibacterial Studies on Cadmium(II)– bis(2,2/-methylidenephenol)diaminoethane

Abstract

The objective of this work is to prepare a new synthetic protocol of the cadmium(II) complex ofbis(2,2’-methylylidenephenol)diaminoethane (H2BMPDE) and study the antimicrobial bioefficacy. In thiswork, we report the extractive method for the synthesis of cadmium(II) complex of bis(2,2’-methylidenephenol)diaminoethane from salicylaldehyde, ethylenediamine, hydrochloric acid, and cadmiumsulfate in a single, simple step. The ligand and the complex were characterized by FTIR, UV-Vis, 1H and 13CNMR, magnetic moment, GC-MS, thermal and elemental analysis. The chemical data indicated theformation of 1:1 (metal:ligand) mole ratio and distorted tetrahedral geometry was suggested as based onspectral data and magnetic moment. The results of preliminary antibacterial study revealed that Cd(II)H2BMPDE complexes prepared from different acids (HCl, HNO3, H2SO4) were effective against clinicallyimportant Gram-negative bacteria (Escherichia coli, pseudomonas, Klebsiella ) and Gram-positivebacterium (Staphylococcus aureus).The result indicated a new synthetic protocol for the synthesis ofH2BMPDE complexes. On the application, H2BMPDE and its complexes could be considered as a potentialantibacterial agent with further investigative analysis.