Synthesis, Characterization, and Carbonic Anhydrase Inhibitory Properties of Silver(I) Complexes of Benzimidazole Derivatives

Abstract

The antimicrobial properties of silver compounds and biological properties ofbenzimidazole derivatives have been well known for many years. In the present study, in terms oftheir biological potential, six novel silver(I)-N-alkylbenzimidazole derivatives were synthesized inorder to examine their carbonic anhydrase (CA) inhibitory properties. All complexes werecharacterized by the combination of 1H NMR, 13C NMR, mass, FT-IR spectroscopic methods andelemental analyses. The inhibitory properties of all complexes were tested on the esterase activityof human CA I and II (hCA I and hCA II). Acetazolamide was used as a standard. All complexesinhibited the hCA I and hCA II activity in the range of 27.37-29.58 µM and 20.93-27.25 µM,respectively.