Synthesis, Characterization, and Molecular Docking Studies of Fluoro and Chlorophenylhydrazine Schiff Bases

Abstract

Six Schiff bases synthesized by condensation reaction of p-fluoro and chlorophenylhydrazineswith some carbonyl compounds were reported in this work. Structures of the prepared compounds wereelucidated by FT-IR, 1H- and 13C-NMR spectroscopy. FT-IR spectra exhibited characteristic transitions forall compounds. Also, their structures were proved by NMR spectroscopy, especially with the imine peakwhich is an indicator of the formation of Schiff bases. In addition, molecular docking studies of the Schiffbases were carried out on Alzheimer’s disease. The calculated docking scores and inhibition constantspointed out the probability of the usage of 2-chloro-5-nitrobenzaldehyde Schiff bases as a new drugcandidate for Alzheimer’s disease after structural regulations.