Study on the Preparation and Drug Release Property of Modified PEG-DA Based Hydrogels

Abstract

The aim of the present study is to develop hydroxyapatite-modified PEGDA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potentialtreatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure651), 1 hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photoinitiators in the synthesis of hydrogels and hydroxyapatite was used for modifyinghydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electronmicroscope (SEM) and digital microscope were utilized to investigate the characteristicproperties of hydrogels. Photopolymerization technique was selected for the synthesisof hydrogels. Swelling and drug release studies have been performed under differentpH conditions.