A Novel ZnO Nanoparticle as Drug Nanocarrier in Therapeutic Applications: Kinetic Models and Error Analysis

Abstract

Nanotechnology provides promising possibilities for several biomedical and pharmaceuticalapplications in the medical industry. Nanostructures play a major role in the recent strategies of technologysuitable for novel drug applications. In this work, clindamycin phosphate (CliP) (topical anti-inflammatorydrug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle) nanostructures weresynthesized using the sonochemical technique at room temperature. The characterization of theclindamycin phosphate-xanthan gum/ZnO (CliP-XaG/ZnO) nanostructure has been carried out by Fouriertransform infrared (FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated the invitro mechanism of drug delivery system at different pH media (1.2 and 7.4). In this study, theconcentration of the drug in the solution was analyzed by UV–Vis spectrophotometric method and detailederror analysis were performed. The Higuchi gave the best correlation with the experimental data. Theswelling behavior of the nanostructure was studied. The percentage of the swelling ratio of XaG/ZnOexerted a more significant effect than XaG at pH 1.2 and pH 7.4. The results show that the capacity of XaG/ ZnO can be preferred as a novel topical anti-inflammatory drug carrier.