Synthesis of Isatin and its Derivatives Containing Heterocyclic Compounds

Abstract

Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and itsanalogs are synthetically useful substances where they may be utilized for the production of abroad range of heterocyclic molecules, which are depicting a wide reach of biological andpharmacological activities, as well as anticancer, anti-inflammatory, antiviral, anticonvulsant, antiTB, antidiabetic, anti-microbial, antitumor, antimalarial, anti-HIV, antibacterial, anti-analgesic, andantiplasmodial activities. Isatin is a precursor for many synthesized therapeutic molecules that areamenable to pharmacological action and have excellent biological potential. Isatin has amagnificent scaffold for both the natural and synthetic construction of molecules. These moleculesare being used in drug therapy such as anticancer, antibiotic, and antidepressant drugs and havemany more clinical applications. Due to its privileged scaffolding, the synthetic versatility of isatinhas produced many structurally diverse derivatives, including the substitution of mono-, di- and trisubstitution of the aryl rings A and those derived by derivation of isatin nitrogen and C2 and C3carbon moieties. As a result, improving and expediting access to isatin-related molecules is achallenging study in synthetic organic chemistry.