INVESTIGATION OF THE EFFECTION MECHANISM OF CINNAMIC ACID ON CONTRACTION AND RELAXATION OF SMOOTH MUSCLES OF ILEUM AND BLADDER OF RATS

Abstract

Cinnamic Acid is a phenolic acid derivative commonly found in Cinnamomi cortex (Cinnamon) plant,and it is named after cinnamon plant. It have Antimicrobial, Antitumoral, Anticancer and Antifungalproperties and beyond that its vasodilator effect were also detected.This study was performed separately for ileum and bladder in 7 different groups, namely atropine,phentolamine, propranolol, nifedipine, tetraethyl ammonium and atropine + phentolamine +propranolol applied groups. In the study, the contraction-relaxation responses to cinnamic acid of therelevant tissues were examined after application of different antagonists or channel blockers to KCl orcarbachol pre-contracted ileum / bladder tissues.Cinnamic acid caused constraction and relaxation of the ileum and bladder as dosage dependentmanner. Atropine did not change the relaxation response while further contracting the ileum. Itincreased relaxation while inhibiting contraction responses in bladder. The contraction and relaxationresponses of phentolamine on ileum and bladder was not changed. The propranolol inhibited thecontraction responses of ileum, but did not change the relaxation responses. In bladder, the contractionresponses increased, but relaxation responses did not change. Nifedipine did not alter the relaxationresponses while inhibiting the response of contraction to cinnamic acid in ileum, and increasingrelaxation responses without affecting the contraction responses in the bladder. TEA increasedrelaxation responses while it did not affect the contraction responses in bladder, but did not changecontraction and relaxation responses in ileum. At the same time, the adrenergic and cholinergicreceptor blockade performed at the same time altered the contraction and relaxation responses in theileum and bladder, but did not significantly affect them.In conclusion, it is thought that cinnamic acid applied on rat ileum and bladder smooth muscles, isalso influenced by different receptors or pathways other than receptor antagonists and channelblockers preferred by us.