Formulation and evaluation of lansoprazole sublingual tablet

Abstract

The objectives of present investigation is to improve the solubility and rate of dissolution of poorlyaqueous soluble drug lansoprazole by preparing solid dispersion with amphiphilic carrier Soluplus in 1:2concentration by using solvent evaporation method, solvent melting method and microwave oven method andselecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion wasperformed by FTIR and DSC. These study showed no interaction in drug and carrier. The sublingual tablet representsan innovative drug delivery system, sublingual tablet of lansoprazole was formulated by incorporating selected soliddispersion with combination of novel superdisintegrants and taste maskers like Indion – 414 and Kyron T – 314 byusing direct compression method. The sublingual tablet showed the rapid disintegration within average 32 seconds.All the evaluations were performed and complies with the pharmacopoeial standards. The drug and excipientcompatibility study of lansoprazole sublingual tablet was also performed by FTIR and DSC. These study showed nointeraction in drug and excipients. The formulation F9 (12 % superdisintegrants) showed 98.42% of cumulative drugrelease within 8 min with zero order release pattern. These novel formulation lansoprazole sublingual tablet showedquick on set of action and may be found to be beneficial, convenient for pediatrics, geriatrics, and psychiatric patientsand patients with swallowing difficulties and in situations where water is not available.