In vitro effects of methylsulphonylmethane in MCF7 cells

Abstract

Methylsulphonylmethane (MSM) is the best source of organic sulfur with the best bio-utilization in thebody. MSM provides Sulphur support to fragile tissues such as hair. It provides elasticity to connective tissue. It isrequired for collagen production. Despite its many advantages, there are only few published papers about the anticancerresearch regard to MSM, no known studies on Bioinformatics Analysis and the possible mechanisms such an effect remainunknown. Therefore, we aimed to investigate the anticancer effects of MSM associated with a bioinformatics analysis onthe breast cancer cell MCF7 and to give the information about possible molecular mechanisms. A cytotoxicity assay wasperformed using the MTT method. The cell migration analysis was performed using wound healing analysis. Anapoptotic effect was performed by DNA fragmentation analysis. A Bioinformatics analysis was performed using a proteindata bank. Study results indicated that this component exhibited an anti-proliferative effect as based on dosage increasesand it showed apoptotic effects at high concentrations on MCF7 cells and results were supported by previous studies.Consequently, a detailed study of the molecular mechanisms of this matter would allow for the identification of possiblenew targets for breast cancer treatments